A plausible mechanism has emerged which suggests that cyclooxygenase-2 (COX-2) inhibitors might expose otherwise predisposed individuals to thrombotic or systemic hypertensive complications. There is ...

All NSAIDs variably inhibit COX-1 and COX-2 and the mechanisms of inhibition fall into three broad categories, although there are exceptions. For example, nimesulide is a weak competitive inhibitor of ...

Cyclooxygenase-2 (COX-2) is overexpressed in lung cancer, especially in adenocarcinoma (ADC). Our aim was to determine the prognostic value of COX-2 on survival in patients with lung cancer. Studies ...

The painkillers that can cause heart attacks are staging a comeback. Will the drive for profits once again trump sound science and proper medical practice? Vioxx and Celebrex are the best-known drugs ...

Researchers have few tools for understanding what happens in the brain at the earliest stages of neuroinflammatory disorders such as Alzheimer’s or Huntington’s disease. A new signaling molecule that ...

This issue of examines interventions aimed at improvingdrug safety. 1-4 The need for a rigorous researchagenda in pharmaceutical safety is highlighted byMerck's ...

COX-2 selective inhibitor is a form of Non-steroidal anti-inflammatory drug (NSAID) that directly targets COX-2, an enzyme responsible for inflammation and pain. Selectivity for COX-2 reduces the risk ...

UPSTREAM, DOWNSTREAM: Biochemical activity upstream of cyclooxygenase is better understood than reactions downstream of the enzyme. Cancer, Alzheimer's disease, and stroke represent disparate ...

The recall of rofecoxib (Vioxx) raises the question of whether the heart attack and stroke risks uncovered in recent research are unique to this drug or common to other COX-2 inhibitors, the Oct. 9 ...

Dublin, Nov. 28, 2024 (GLOBE NEWSWIRE) -- The "COX-2 Selective NSAIDs Market by Application, End-User, Drug Type, Dosage Form - Global Forecast 2025-2030" report has been added to ...

BAE: Bovine aortic endothelial; RHP: Recombinant human protein. NSAIDs variably inhibit prostaglandin H synthase (COX). COX-2 was cloned in 1991, and it was subsequently established that COX-1 does ...