The reactivity and relative rarity of most cofactors pose challenges for their delivery to target enzymes. Using kinetic analyses, we demonstrate that adenosyltransferase, which catalyzes the final ...

The mechanism by which docking fidelity is achieved for the multitude of cofactor-dependent enzymes is poorly understood. In this study, we demonstrate that delivery of coenzyme B₁₂ or ...

A study conducted in C. elegans nematode roundworms may lead to improved treatment of a rare human genetic disorder that causes severe neurological symptoms leading to death in early childhood. A ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 119, No. 14 (April 5, 2022), pp. 1-11 (11 pages) Coenzymes distribute a variety of chemical moieties throughout ...

Coenzyme A is a cofactor in enzymatic acyl transfer reactions. It participates in the biosynthesis and oxidation of fatty acids and the oxidation of pyruvate in the citric acid cycle. It was ...