Although distinct in structure and function, cohesin and condensin both contain conserved chromosomal ATPases of the structural maintenance of chromosomes (SMC) protein family. Present models indicate ...

The multisubunit condensin complex is essential for the structural organization of eukaryotic chromosomes during their segregation by the mitotic spindle, but the mechanistic basis for its function is ...

Scientists have discovered how condensin keeps chromosome arms folded and easy-to-transport during cell division, potentially acting as a cord-stopper. As any rock-climber knows, trailing a long ...

Scientists have identified how a specific variant of a key protein complex found in human cells called condensin can reorganize a cell's genetic architecture in such a way as to promote senescence, ...

This is a preview. Log in through your library . Abstract The machinery mediating chromosome condensation is poorly understood. To begin to dissect the in vivo function(s) of individual components, we ...

The paper M. Ganji et al., “Real-time imaging of DNA loop extrusion by condensin,” Science, doi:10.1126/science.aar7831, 2018. How does a human cell neatly pack ...

The most accurate quantitative model yet for understanding the role of condensin during cell division is also visually stunning. A team of scientists from UT Austin have developed the most accurate ...

The first theoretical model of condensin, a molecular machine involved in packing and unpacking chromosomes, accurately reproduces all known experiments with just two parameters. To scrunch a ...

Frog egg extracts have yielded insights into the intricacies of what happens to chromosomes when our cells divide Experiments using extracts from African clawed frog eggs have revealed how a key ...

After confirming the interactions between condensin I/II and BMI1s, they are discovered to co-regulate CD structure and the expression of portion of genes. Disclaimer: AAAS and EurekAlert! are not ...

Stress can make you wish life had a pause button. Single-celled organisms like yeast actually have this option. Faced with a lack of food or other stressors, baker’s yeast can enter a “paused,” energy ...

A mixture of DNA and proteins—known as "chromatin"—sits inside every cell nucleus as a jumbled puddle of genetic information. As cells prepare to divide during mitosis, the chromatin is condensed into ...