SGLT2 inhibitors (gliflozins) were developed as oral antidiabetics. They enhance urinary glucose excretion by inhibiting SGLT-2 (sodium-dependent glucose co-transporter-2) in the renal tubuli. The ...

Renal fibrosis, particularly tubulointerstitial fibrosis, is the common final outcome of almost all progressive chronic kidney diseases. Renal fibrosis is also a reliable predictor of prognosis and a ...

Eleven of 13 patients with far advanced chronic renal disease of diverse etiologies were found to have urine that remained hypotonic to plasma in spite of the administration of a supramaximal dose of ...

Niigata, Japan - The gold standard test for predicting the onset of diabetic kidney disease is albuminuria. However, detecting albuminuria alone has limited sensitivity and specificity in end-stage ...

Urea transporter (UT) proteins facilitate the passive transport of urea driven by a concentration gradient across the cell plasma membrane in some kidney and extrarenal cells The kidney expresses ...

Researchers uncover a previously unrecognized mechanism that may accelerate polycystic kidney disease. For people with polycystic kidney disease (PKD), life can be a constant cycle of symptoms: aches ...

(Beyond Pesticides, October 1, 2025) A novel study in Scientific Reports combines computational analyses with toxicological data to identify pathways affected by exposure to the weed killer glyphosate ...