Protein folding in the endoplasmic reticulum (ER) is assisted by several molecular chaperones and folding factors. These proteins are key players in the quality-control (QC) system, which regulates ...

Macrophages accumulate free cholesterol in advanced atherosclerotic lesions, resulting in macrophage apoptosis and progression of lesions 1,2,3,4,5,6,7,8. Previous studies with cultured macrophages ...

The endoplasmic reticulum is the protein-making factory within cells consisting of tightly stacked sheets of membrane studded with the molecules that make proteins. Now, researchers have refined a new ...

The Golgi body (or Golgi complex, apparatus), and Endoplasmic reticulum (ER) are both organelles found in the majority of eukaryotic cells. They are very closely associated and show both similarities ...

Calcium (Ca2+) drives many cellular functions, though the way it controls quality of proteins in the endoplasmic reticulum ...

Calcium (Ca2+) drives many cellular functions, though the way it controls quality of proteins in the endoplasmic reticulum ...

Calcium is one of the most important minerals for body as well as cellular functions.But the way it controls the quality of ...

Calcium-dependent phase separation of PDIA6. Top: Discovery of the "phase separation" phenomenon of PDIA6 in a test tube experiment: Addition of calcium to a PDIA6 solution leads to the formation of ...

3D electron tomography reveals glycogen particles (purple) clustered on the surface of lipid droplets (yellow), closely associated with endoplasmic reticulum membranes (blue) and mitochondria (red), ...