WRN is unique among the five human RecQ DNA helicases in having a functional exonuclease domain (WRN-exo) and being defective in the premature aging and cancer-related disorder Werner syndrome. Here, ...
Mitochondrial DNA (mtDNA) polymerase γ (POLγ) harbours a 3′–5′ exonuclease proofreading activity. Here we demonstrate that this activity is required for the creation of ligatable ends during mtDNA ...
Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, No. 27 (Jul. 8, 2008), pp. 9169-9174 (6 pages) Bacterial single-stranded DNA (ssDNA)-binding proteins (SSBs) ...
This is a preview. Log in through your library . PNAS is the world's most-cited multidisciplinary scientific serial. It publishes high-impact research reports, commentaries, perspectives, reviews, ...
Homologous recombination is a DNA repair mechanism that counteracts double-stranded breaks in DNA. Researchers at Kindai University have recently revealed how the Sae2 protein coordinates with the ...
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