This Brush Up is sponsored by Cayman Chemical. Learn more about chemical inhibitors of histone modification. Histone modification affects how tightly DNA wraps around histone proteins, yielding ...

Key modifications involved in HCC include lysine methylation and acetylation, regulated by KMTs/KDMs and HATs/HDACs, respectively, which influence chromatin accessibility and transcriptional activity.

Histone Kla regulates tumor angiogenesis by affecting the levels of downstream HIF1-ɑ and Vegf. In non-histone proteins, YY1-Kla influences FGF2, and Sema3A-Kla affects HIF1-ɑ, both contributing to ...

A molecular model showing three of the main epigenetic modifications of DNA (orange) and histones (dark blue) [JUAN GAERTNER/Science Photo Library/Getty Images] Post-translational modifications (PTMs) ...

These modifications increase chromatin accessibility, influencing growth, differentiation, and ion transport, with contrasting effects on normal and colorectal cancer cells. Study: Short-chain fatty ...

Lactylation, a recently identified post-translational modification, has emerged as important for immune regulation, tissue repair, cancer cell metabolism, and now, potentially, Alzheimer’s disease. In ...

Winnie Chen (left) is an MD PhD student in the lab of Ian Maze at Mount Sinai (NY, USA). Winnie’s current work is focused on understanding the role of dopamine in Parkinson's disease. The lab is ...