The Castagnoli-Cushman reaction constitutes a versatile multicomponent approach for the synthesis of nitrogen heterocycles, particularly lactams. Traditionally involving the cycloaddition of ...

Researchers have simplified the operation of an important class of chemical transformation: synthesis of beta-lactams, the intricate scaffold of many antibiotics. Their experimental protocol minimizes ...

Synthetic chemists can go around in circles trying to make the cyclic amides known as lactams. That’s because lactams with 4-, 5-, and 6-membered rings—known as β-, γ- and δ-lactams, respectively—are ...

The team, led by Professor Seo Sang-won from DGIST's Department of Chemical Physics, in collaboration with the Molecular Activation Catalysis Research Team of IBS (headed by Professor Seok-bok Jang ...

Osaka, Japan – While we appear to live in a world of plenty, behind the scenes, sourcing sufficient amounts of key ingredients can be challenging. For example, the synthesis of certain antibiotics, ...