Altered intestinal barrier function is postulated to be a central predisposing factor to intestinal diseases, including inflammatory bowel diseases and food allergies. However, the mechanisms involved ...

This scanning electron microscopy image captures the moment where degranulating mast cells (pseudo-colored in sepia) attract and start to incorporate living neutrophils (pseudo-colored in cyan), ...

Mast cells are pivotal effectors in immune responses, acting as both sentinels and mediators in allergic and inflammatory processes. Their ability to rapidly degranulate and release a myriad of ...

Eosinophils and mast cells are two types of immune cells with critical roles in responding to foreign assaults. When these cells do not function properly, several disease outcomes can develop (e.g.

Third in a series of articles on COVID-19 and its effects on the gut, this article will explore “Long COVID” (also called “post-acute COVID syndrome”) and the role mast cells play in producing gut ...

In early 2020, Wynde Dyer walked into the house that would transform her life. The Central California ranch sat on a cul-de-sac of gated homes and glittering aquamarine pools. It boasted private ...

Barzolvolimab achieved sustained complete responses and improved quality of life in patients with CSU up to 76 weeks post-treatment. The therapy targets mast cells by inhibiting receptor tyrosine ...

Depending on one's perspective, "mast cell activation syndrome (MCAS)" is either a relatively rare, narrowly defined severe allergic condition or a vastly under-recognized underlying cause of multiple ...