Nature

2015 Nobel Prize in Chemistry

Nucleotide excision repair is one of the main pathways for removal of damaged DNA. UvrA, which finds the damaged DNA, has broad specificity. The first crystal structure of UvrA in complex with DNA ...
ascopubs.org

Mismatch repair (MMR) and base excision repair (BER) protein expression correlates with clinical response to dacarbazine (DTIC)/temozolomide (TMZ) therapy of patients with ...

Phase II study of the farnesyltransferase inhibitor R115777 in advanced melanoma: CALGB 500104 No significant financial relationships to disclose. This is an ASCO Meeting Abstract from the 2006 ASCO ...
The Atlantic

The Nobel Prize and Mechanistic DNA Repair

This year’s Nobel Prize in Chemistry has been awarded jointly to Tomas Lindahl, Paul Modrich, and Aziz Sancar for their work on the mechanistic studies of DNA repair. Their worked mapped at a ...
NPR

3 Scientists Win Nobel Prize In Chemistry For DNA Repair Research

Their work details how cells repair damaged DNA and preserve genes. And now three scientists — Tomas Lindahl, Paul Modrich and Aziz Sancar — have won the 2015 Nobel Prize in Chemistry. Their work ...
ascopubs.org

DNA Repair Pathways in Clinical Practice: Lessons From Pediatric Cancer Susceptibility Syndromes

Human cancers exhibit genomic instability and an increased mutation rate due to underlying defects in DNA repair. Cancer cells are often defective in one of six major DNA repair pathways, namely: ...