Protein disaggregation is a critical cellular process wherein misfolded or aggregated proteins are solubilised and, in many cases, returned to their native configurations. Chaperone systems, including ...
The first full-length structures of two heat shock chaperone proteins in a complex reveal the key structural region regulating their function, according to a new study from St. Jude Children's ...
When exposed to stressful conditions, several proteins tend to misfold and form aggregates inside or outside cells. These aggregates, if accumulated, may contribute to age-related disorders, including ...
Proteins tend to fold wrongly and become defective when exposed to stressors such as heat, oxidation, and pH changes. Accumulation of abnormal proteins contributes to neurodegenerative diseases like ...
The biology of histone proteins encompasses their synthesis in the cytosol, nuclear import and incorporation into nucleosomes, as well as subsequent eviction from chromatin, redeposition, storage or ...
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First complete structures of heat shock chaperone protein complex reveal handoff mechanism
The first full-length structures of two heat shock chaperone proteins in a complex reveal the key structural region regulating their function, according to a new study from St. Jude Children's ...
Numerous BYU students, including Mikaila Sass (pictured), worked with Dr. Willardson in his lab on this discovery. The human body heavily relies on protein molecules for proper functioning. Protein ...
New research describes a 'chaperone' protein that delivers zinc, a trace element essential for survival in all living things, to where it's needed. The chaperone could be especially important when ...
Membraneless organelles contain a wide spectrum of molecular chaperones, indicating their important roles in modulating the metastable conformation and biological function of membraneless organelles.
Researchers from the Keck School of Medicine of USC used imaging techniques to study how the protein GRP78 controls cancer cell behavior. In the top row, human lung cancer cells were engineered to ...
A new study has found that treatment with a ‘chemical chaperone’ assists in reducing the accumulation of protein plaques and restores cognitive functioning in mouse models of Alzheimer’s disease. The ...
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