Researchers have identified a specific structural change in the brain that appears to track with the relief of depressive symptoms following ketamine treatment. In a group of patients with ...

Ketamine, an increasingly popular depression treatment, affects the brain like fentanyl and oxycodone, according to a study published in The American Journal of Psychiatry. 1. Ketamine started as an ...

Ketamine is a highly effective, fast-acting antidepressant that works even for patients who have not responded to other medications. However, the brain mechanisms important for these rapid treatment ...

Activation of the body’s opioid system may be required for ketamine’s antidepressant effects, new research hinted. In a small study of adults with major depressive disorder, taking the opioid blocker ...

Jacintha was at her wits' end. Her daughter was struggling, and they had tried everything ‒ two types of antidepressants, years of talk therapy and weeks of an intensive outpatient program. There was ...

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An important study published in JAMA Psychiatry (2025) challenges some of the most popular narratives about ketamine’s effectiveness as a rapid antidepressant, underscoring the crucial role of context ...