The re-transcribed DNA is then integrated into the genome of the host cell (Figure 2). This process requires the absence of the nuclear membrane and thus is restricted to the M-phase of proliferating ...

Expert Rev Proteomics. 2008;5(3):507-528. Although it is widely known that HIV-1 initiates a profound global host cell response to infection, it is difficult to trace specific expression and pathway ...

A chemical modification in the HIV-1 RNA genome whose function has been a matter of scientific debate is now confirmed to be key to the virus's ability to survive and thrive after infecting host cells ...

The MCM helicase is broadly bound across the genome, and its phosphorylation is antagonistically regulated by the kinase DDK and the phosphatase RIF1–PP1. TRESLIN–MTBP recognises the phosphorylated ...

In a groundbreaking discovery, researchers from Florida Atlantic University’s Charles E. Schmidt College of Medicine have identified a never-before-seen mechanism that enables the human ...

If the engines of DNA replication stay in high gear all the time, they eventually stall or even break down. Fortunately, these engines, which consist of protein complexes, have what could be called ...

Charles Darwin proposed that evolution is driven by gradual variations in organisms that have a survival advantage in a changing environment. But University of Maryland evolutionary biologist Karen ...

From the Bedalov Lab, Translational Science and Therapeutics and Human Biology Divisions When I asked Foss and Bedalov whether the known replication origins in yeast shared any sequence-level features ...

Researchers have discovered how cells activate a last-resort DNA repair system when severe damage strikes. When genetic ...

When cells proliferate, genomic DNA is precisely duplicated once per cell cycle. Abnormalities in this DNA replication process can cause alterations in genomic DNA, promoting cellular aging, cancer, ...