The tide of the blood coagulation cascade turns by a switch in thrombin specificity. Two new structures reveal how thrombomodulin's EGF domains flip the switch by blocking old substrates and docking ...

STOCKHOLM, Sweden – An experimental agent that prevents the formation of blood clots earlier in the coagulation process than other agents has cleared its first hurdle in becoming a potential new ...

Blood coagulation is a balancing act. Too much clotting can lead to strokes. But not enough clotting can lead to uncontrolled bleeding. That balance is particularly important for patients with ...

Charlottesville, VA (March 6, 2012). Clinicians from the University of Utah report the death of a patient who received a mild brain injury from a ground-level fall while taking the new anticoagulant ...