We present a yeast chemical-genomics approach designed to identify genes that when mutated confer drug resistance, thereby providing insight about the modes of action of compounds. We developed a ...

cdc28, one of several genes required for cell division in the yeast Saccharomyces cerevisiae, has been isolated on recombinant plasmids. A recombinant plasmid pool containing the entire yeast genome ...

The inner nuclear membrane of eukaryotic cells defines many aspects of gene expression and chromatin organization. It is also therapeutically important as several diseases, termed “laminopathies” are ...

This is a preview. Log in through your library . Abstract Complementation has been observed in cytoplasmic respiratory deficient yeast cells (petites) to yield respiratory competent diploids. This ...

Apoptosis, often referred to as programmed cell death, is a fundamental process crucial to the growth and development of multicellular organisms. This process, or a primordial form of it, is also ...