Translation is the process by which a protein is synthesized from the information contained in a molecule of messenger RNA (mRNA). During translation, an mRNA sequence is read using the genetic code, ...
Deep in the protein translation machinery are cogs known as transfer RNAs, or tRNAs. Actually, they may be more than mere cogs, say scientists at the University of Chicago. Like other components of ...
Daisuke Kiga, Kensaku Sakamoto, Koichiro Kodama, Takanori Kigawa, Takayoshi Matsuda, Takashi Yabuki, Mikako Shirouzu, Yoko Harada, Hiroshi Nakayama, Koji Takio, Yoshinori Hasegawa, Yaeta Endo, Ichiro ...
The antibiotic blasticidin S (BlaS) is a potent inhibitor of protein synthesis in bacteria and eukaryotes. We have determined a 3.4-Å crystal structure of BlaS bound to a 70S-tRNA ribosome complex and ...
For many years, scientists believed that transfer RNAs are simple shuttles that bring amino acids to ribosomes. But a growing number of studies find that they can alter important cellular processes by ...
Between 10 to 15% of all genetic diseases have the same underlying cause: a nonsense mutation. 1 This type of mutation results from a stop codon in the middle of a gene sequence, which terminates ...
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