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Figure 1: Histone H3.3 Ser31 becomes phosphorylated along arms of misaligned chromosomes. To accentuate this difference, we used nocodazole treatment to depolymerize microtubules, allowing the mitotic ...

Cleavage of cohesins and cyclin-dependent kinase (CDK) inhibition are thought to be sufficient for triggering chromosome segregation. Here we identify an essential requirement for anaphase chromosome ...