Gain-of-function research (GoF research or GoFR) is medical research that genetically alters an organism in a way that may enhance the biological functions of gene products.

Jan 30, 2025 · “Most of the time, when you hear someone say ‘gain of function,’ they mean an effort on the part of researchers to select for the increased ability of a pathogen — a bacteria, virus or …

Sep 9, 2021 · The term ‘gain of function’ is perhaps one of the most misunderstood in the scientific lexicon. I would like to explain what the phrase means from the perspective of a scientist who has …

May 8, 2023 · The term “gain of function” is often taken to refer to research with viruses that puts society at risk of an infectious disease outbreak for questionable gain.

Gain of function research is a term that refers to techniques used in research to alter the function of an organism in such a way that it is able to do more than it used to do, and to understand how this …

Jun 18, 2025 · Gain-of-function research involves modifying organisms, like viruses or bacteria, to enhance their existing attributes or grant them new ones. The process is like tuning a car engine to …

Sep 4, 2022 · Gain-of-function research (GOFR) refers to the serial passaging of microorganisms to increase their transmissibility, virulence, immunogenicity, and host tropism by applying selective...

Gain of Function (GoF) Q&A Gain-of-function refers broadly to experimental techniques or natural processes that result in an organism acquiring new, or enhanced, biological traits.

Jun 21, 2021 · What does gain of function mean? Any organism can acquire a new ability or property, or “gain” a “function.” This can happen through natural selection or a researcher’s experiments. In …

Jun 21, 2021 · What does gain of function mean? Any organism can acquire a new ability or property, or “gain” a “function.” This can happen through natural selection or a researcher’s experiments. In …