Acemannan was first identified in the inner gel of Aloe barbadensis Miller in the mid-20th century, but it wasn’t until the 1970s–1990s that researchers realized this acetylated polysaccharide wasn’t just a “plant sugar”… it directly interacted with immune signaling pathways. Multiple clinical & preclinical studies showed it could safely support macrophage activation, wound healing, balanced cytokine modulation & even assist the body’s natural antiviral & regenerative responses without toxicity.
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